The Pancreas, Książki, Biochemia
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The Pancreas:
An Integrated Textbook of Basic
Science, Medicine, and Surgery
The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition
Edited by H. G. Beger, A. L. Warshaw, M. W. Büchler, R. A. Kozarek, M. M. Lerch, J. P. Neoptolemos,
K. Shiratori, D. C. Whitcomb, and B. M. Rau © 2008 Blackwell Publishing Limited, ISBN: 978-1-405-14664-7
 The Pancreas:
An Integrated Textbook
of Basic Science,
Medicine, and Surgery
Hans G. Beger
MD FACS(Hon)
Founding Editor
Emeritus Professor of Surgery
c/o Universitätsklinikum Ulm
University of Ulm
Germany
John P. Neoptolemos
MA MB BChir MD FRCS FMedSci
The Owen and Ellen Evans Chair of
Cancer Studies
Head, Division of Surgery and Oncology
Head, School of Cancer Studies
Professor of Surgery
University of Liverpool
UK
Andrew L. Warshaw
MD
Surgeon-in-Chief and Chairman
Department of Surgery, Massachusetts
General Hospital
W. Gerald Austen Professor of Surgery
Harvard Medical School
Boston, MA, USA
Keiko Shiratori
MD
Chair and Professor, Department of
Gastroenterology, Tokyo Women’s
Medical University School of Medicine
Tokyo, Japan
Markus W. Büchler
MD
Chairman and Head, Department of
General and Visceral Surgery
Professor of Surgery
University of Heidelberg
Germany
David C. Whitcomb
MD PhD
Professor of Medicine and Chief
Division of Gastroenterology,
Hepatology, and Nutrition
University of Pittsburgh
PA, USA
Richard A. Kozarek
MD
Director, Digestive Disease Institute
Virginia Mason Medical Center
Seattle, WA, USA
Bettina M. Rau
MD
Coordinating Editor
Associate Professor of Surgery
Department of General, Thoracic,
Vascular and Transplantation Surgery
University of Rostock
Germany
Markus M. Lerch
MD FRCP
Professor and Chair, Department of
Gastroenterology, Endocrinology and
Nutrition, Ernst-Moritz-Arndt
University, Greifswald
Germany
SECOND EDITION
© 1998, 2008
Blackwell Publishing Limited
ISBN: 978-1-4051-4664-7
A catalogue record for this title is available from the
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First published 1998
Second edition 2008
Blackwell Publishing makes no representation, express or implied,
that the drug dosages in this book are correct. Readers must
therefore always check that any product mentioned in this
publication is used in accordance with the prescribing information
prepared by the manufacturers. The author and the publishers do not
accept responsibility or legal liability for any errors in the text or for
the misuse or misapplication of material in this book.
1 2008
Library of Congress Cataloging-in-Publication Data
The pancreas: an integrated textbook of basic science, medicine and
surgery/Hans Beger . . . [et al.]. — 2nd ed.
p. ; cm.
Includes bibliographical references and index.
ISBN-13: 978-1-4051-4664-7 (alk. paper)
1. Pancreas—Diseases. 2. Pancreas. 3. Pancreatectomy.
I. Beger, H. G. (Hans G.)
[DNLM: 1. Pancreatic Diseases—physiopathology. 2. Pancreatic
Diseases—therapy. 3. Pancreas—physiology. 4. Pancreatectomy—
methods. WI 800 P18821 2007]
RC857.P282 2007
616.3
7—dc22
2006027480
 Contents
Contributors, ix
15
Acute pancreatitis associated with congenital
anomalies, 163
Tracy C. Grikscheit and Andrew L. Warshaw
Preface, xv
16
Acute pancreatitis associated with metabolic,
infectious, and drug-related diseases, 172
Stefan Turi, Matthias Kraft, and Markus M. Lerch
1
Definitions of pancreatic diseases and their
complications, 1
David C. Whitcomb and Hans G. Beger
17
Acute pancreatitis in children, 184
Mark E. Lowe and Véronique D. Morinville
Section One
Anatomy of the pancreas
18
Understanding of acute pancreatitis from animal
experiments, 193
Thomas Foitzik
2
The history of the pancreas, 9
Irvin M. Modlin, Manish C. Champaneria, Anthony
K.C. Chan, Mark Kidd, and Geeta N. Eick
19
Genetic factors in acute pancreatitis, 200
David C. Whitcomb and Georgios I. Papachristou
3
Development of the pancreas and related structures, 42
Brian Lewis
20
Histopathology of acute pancreatitis, 209
Günter Klöppel
4
Anatomy and fine structure, 50
Dale E. Bockman
21
Molecular, biochemical, and metabolic abnormalities of
acute pancreatitis, 214
Julia Mayerle, F. Ulrich Weiss, Walter Halangk, and
Markus M. Lerch
5
Congenital and inherited anomalies, 58
Martin Zenker and Markus M. Lerch
Section Two
Physiology of pancreatic functions
22
Clinical course of alcoholic acute pancreatitis, 226
Roland H. Pfützer and Manfred V. Singer
6
Physiology of acinar cell secretion, 71
Ole H. Petersen
23
Clinical course and treatment principles of biliary
acute pancreatitis, 231
Julia Mayerle, Ashok K. Saluja, and Markus M. Lerch
7
Physiology of duct cell secretion, 78
Min Goo Lee and Shmuel Muallem
24
Clinical assessment and biochemical markers to
objectify severity and prognosis, 242
Bettina M. Rau
8
Physiology of experimental pancreatitis, 91
Ashok K. Saluja, Vijay P. Singh, and Phoebe Phillips
9
Physiology of sphincter of Oddi function, 107
James Toouli
25
Imaging acute edematous–interstitial and necrotizing
pancreatitis, 255
Patrick C. Freeny
10
Neurohormonal and hormonal control of exocrine
pancreatic secretion, 113
Chung Owyang
26
Treatment of acute pancreatitis, 273
Conservative therapy of acute pancreatitis
Paul Georg Lankisch
ICU treatment of severe acute pancreatitis
Mark Topazian and Henry J. Schiller
11
Regulation of pancreatic protein synthesis and
growth, 127
Maria Dolors Sans, Stephen J. Crozier, and
John A. Williams
27
Bacterial and fungal infections in necrotizing
pancreatitis: pathogenesis, prevention, and
treatment, 288
Bettina M. Rau and Hans G. Beger
12
Insulo-acinar relationship, 136
Keiko Shiratori and Kyoko Shimizu
Section Three
Acute pancreatitis
28
Indications for interventional and surgical treatment
of acute pancreatitis, 298
Thomas E. Clancy and Stanley W. Ashley
13
Etiopathogenesis and epidemiology of alcohol-induced
acute pancreatitis, 145
Minoti V. Apte, Ron C. Pirola, and Jeremy S. Wilson
29
Surgical management of necrotizing pancreatitis, 308
Débridement and continuous closed lavage
Bettina M. Rau and Hans G. Beger
14
Etiology and epidemiology of biliary acute
pancreatitis, 154
Michael G.T. Raraty and John P. Neoptolemos
v
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